Benzene → HCID 178479697, compound

Participants

Reaction Steps

4-Hydroxy-1,5-naphthyridine-3-carboxylic acid was added to a mixture of benzene, 0.73 g of dimethylformamide and 1.56 g of thionyl chloride, and the resulting mixture was stirred at 40° to 85° C for 3 hours. The precipitated crystals were collected by filtration, washed with benzene and dried under reduced pressure to give 2.37 g of 4-hydroxy-1,5-naphthyridine-3-carbonyl chloride hydrochloride as crystals. Purity (determined by NMR analysis as the ester form obtained by further alcoholysis), 96.3%.

Provenance & Evidence