Hydrochloric Acid → HCID 21483629, compound

Participants

Reaction Steps

To a solution of 1 g. of 4-[3-(2-chloroethyl)ureido]-2,2,6,6-tetramethylpiperidine in 8 ml. of 10% hydrochloric acid was added gradually 0.4 g. of sodium nitrite at 0° - 5° C. After completion of the addition, the reaction mixture was stirred at a temperature below 10° C. for additional 1.5 hours. The crystalline substances separated out in situ during the stirring were recovered by filtration, washed with a small amount of cold water and recrystallized from aqueous methanol to give 0.5 g. of the pure hydrochloride.monohydrate of the desired product having pale yellow color and a decomposition point of 159° - 163° C.

Provenance & Evidence