HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-Chloro-6-(1-ethyl)hydrazino-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Ethylhydrazine | HCID 29062 | — |
| Reactant | Ethyl 4,6-dichloro-2-methyl-5-nitropyridine-3-carboxylate | HCID 12387594 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-Chloro-6-(1-ethyl)hydrazino-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester | HCID 86734417 | — |
Reaction Steps
27.9 g. of 4,6-Dichloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester (0.2 mol.) are dissolved in about 100 ml. of methanol and 20 ml. of water. 15 g. of triethylamine are added and at 25°-30° 4.5 g. ethyl hydrazine are dropped in with stirring. After the addition is complete, stirring is continued for 1 additional hour. On cooling, 4-chloro-6-(1-ethyl)hydrazino-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester precipitates, yield 19.7 g. (65%) m.p. 117°-120°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04003908 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-c97ae0e29fec493d9231b8ce306a9ac2 |
| Source note | uspto-grants-1977_01 |