HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylhydrazine → 4-Chloro-6-(1-methyl)hydrazino-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | Ethyl 4,6-dichloro-2-methyl-5-nitropyridine-3-carboxylate | HCID 12387594 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Chloro-6-(1-methyl)hydrazino-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester | HCID 12387613 | — |
Reaction Steps
27.9 g. of 4,6-dichloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester (0.1 mol.) are dissolved in about 100 ml. methanol. At 50° C., 9.2 g. of methylhydrazine are dropped in and the mixture is stirred for 30 minutes. On cooling 4-chloro-6-(1-methyl)hydrazine-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester precipitates. Yield 18 g. (62.2%), m.p. 159°-161° (methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04003908 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-b41fcedc1bbf4b978e76b6f8a251bb26 |
| Source note | uspto-grants-1977_01 |