Acetic Acid → HCID 12387646, compound

HRID 1415146Notes

Reaction equation

HRID 1415146 reaction equation
[NH2:1][C:2]1[C:3]([O:17][CH2:18][CH3:19])=[C:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:5]([CH3:11])=[N:6][C:7]=1[NH:8][CH2:9][CH3:10].[C:20](O)(=O)[CH3:21]>>[CH3:10][C:9]1[N:8]([CH2:20][CH3:21])[C:7]2=[N:6][C:5]([CH3:11])=[C:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:3]([O:17][CH2:18][CH3:19])=[C:2]2[N:1]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 86734421HCID 86734421, compound

Product 1

HCID 12387646HCID 12387646, compound

Procedure

Crude 5-amino-4-ethoxy-6-ethylamino-2-methylpyridine-3-carboxylic acid, ethyl ester is refluxed in acetic acid overnight. The solvent is distilled off and the residue, 2,5-dimethyl-7-ethoxy-3-ethyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid, ethyl ester is recrystallized from petroleum ether, m.p. 62°-65° .

Workup

  1. distillationThe solvent is distilled off
  2. customthe residue, 2,5-dimethyl-7-ethoxy-3-ethyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid, ethyl ester is recrystallized from petroleum ether, m.p. 62°-65°

Sources & evidence

ORD record
ord-da9a5eb065fa45cfaafa38655634c5db
Source dataset
uspto-grants-1977_01
Patent number
US04003908

Reaction notes

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