2,3-Dimethylanisole → HCID 12704542, compound

Participants

Reaction Steps

It is equally suitable to employ an equimolar amount of 2,3-dimethylanisole, or 2-halo-3-methylanisoles such as 2-chloro-3-methylanisole; and 2-methyl-3-haloanisoles such as 2-methyl-3-chloroanisole in Step 1 in place of the 2,3-dichloroanisole used therein to obtain the corresponding 3-(2,3-dimethyl-4-methoxybenzoyl)propionic acid, 3-(2-chloro-3-methyl-4-methoxybenzoyl)propionic acid and 3-(2-methyl-3-chloro-4-methoxybenzoyl)propionic acid, which, in turn, are used in equimolar amount to substitute for the 3-(2,3-dichloro-4-methoxybenzoyl)propionic acid used in Step 2 to obtain the corresponding 4-(2,3-dimethyl-4-methoxyphenyl)butyric acid, 4-(2-chloro-3-methyl-4-methoxyphenyl)butyric acid; and 4-(2-methyl-3-chloro-4-methoxyphenyl)butyric acid.

Provenance & Evidence