Phosphorus pentachloride → HCID 21483939, compound

Participants

Reaction Conditions

Reaction Steps

2-Cyclopentyl-4-(3,4-dichloro-5-methoxyphenyl)-butanoic acid (13.1 g., 0.04 mole), dry benzene (100 ml.) and phosphorous pentachloride (7.5 g., 0.034 mole) are refluxed for one hour with stirring. The mixture is cooled to 5° C. and anhydrous stannic chloride (5 ml.) in dry benzene (25 ml.) is added portionwise. The mixture is allowed to warm to 20°-25° C. and kept for 24 hours after which it is poured into ice water. The organic material is extracted with a suitable solvent. The extract is washed, dried and evaporated to obtain 2-cyclopentyl-6-methoxy-7,8-dichloro-1-tetralone.

Provenance & Evidence