Ethyl bromoacetate → HCID 21483949, compound

Participants

Reaction Steps

2-Cyclopentyl-6-hydroxy-7,8-dichloro-1-tetralone (9.45 g., 0.03 mole) is heated in a mixture of potassium carbonate (5.52 g.) and ethyl bromoacetate (6.68 g., 0.04 mole) in DMF 70 ml.) at 55°-60° C. for three hours. Potassium hydroxide (2.24 g., 0.04 mole) is added. This solution is added to the reaction mixture and the whole is refluxed for 1 hour. Most of the methanol is evaporated and the residue is added to water (ca. 200 ml.). The solid that separates upon acidification is collected, washed with water and crystallized from ethanol to obtain (1-oxo-2-cyclopentyl-7,8-dichloro-1,2,3,4-tetrahydro-6-naphthyloxy)acetic acid.

Provenance & Evidence