Water → HCID 14257701, compound

Participants

Reaction Conditions

Reaction Steps

Chromium trioxide (28 g., 0.028 mole) in 83% acetic acid (12 ml.) is added slowly at 0° C. to a stirred solution of 5,6-dichloro-7-methoxytetralin (4 g., 0.073 mole) in a mixture of acetic acid (90 ml.) and propionic acid (20 ml.). The resulting dark mixture then is kept for 20 hours at 20°-25° C. The resulting dark green solution is poured into a mixture of water (900 ml.) and 96% H2SO4 (10 ml.). The mixture is heated to 70° C., cooled to 0° C. and the precipitate is collected, washed with water, and dried. The dried product is sublimed twice at 100° C. at ca. 0.5 mm. and then crystallized from methanol to obtain 6-methoxy-7,8-dichloro-1-tetralone (1 g.), melting point 132°-132.5° C. The identity of the product is established by proton magnetic resonance (pmr).

Provenance & Evidence