Ethyl bromoacetate → HCID 21483911, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 6-hydroxy-7,8-dichloro-1-tetralone (1 g., 0.0044 mole), potassium carbonate (10.69 g., 0.005 mole) and ethyl bromoacetate (0.84 g., 0.005 mole) in DMF (20 ml.) is heated at 60° C. for 11/2 hours. A solution of potassium hydroxide (0.45 g., 0.008 mole) in methanol (40 ml.) is added, the mixture is refluxed for one-half hour and then poured into water (ca. 500 ml.). Upon acidification a white powder separates. It is collected, washed with water, dried and crystallized from ethanol to obtain (1-oxo-7,8-dichloro-1,2,3,4-tetrahydro-6-naphthyloxy)-acetic acid (1.1 g.), melting point 250°-252° C.

Provenance & Evidence