Hydrochloric Acid → HCID 178515107, compound

Participants

Reaction Steps

To 2-cyclopentyl-6-cyanomethoxy-7,8-dichloro-1- tetralone (5.6 g., 0.0165 mole) in DMF (25 ml.) is added sodium azide (12.6 g., 0.0194 mole) and ammonium chloride (1.05 g., 0.0194 mole). The mixture is heated at 85°-90° C. for one hour, cooled and poured into ice water. The mixture is acidified with 6 N HCl. The dark gummy solid that forms is triturated with butyl chloride to obtain a solid, which is crystallized from a mixture of butyl chloride and methanol to obtain 2-cyclopentyl-6-(5-tetrazolylmethoxy)- 7,8-dichloro-1-tetralone.

Provenance & Evidence