Benzosuberone → HCID 21483890, compound

HRID 1415209Notes

Reaction equation

HRID 1415209 reaction equation
C[O:2][C:3]1[C:4]([Cl:16])=[C:5]([Cl:15])[C:6]2[C:12](=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:14]=1.Cl.N1C=CC=CC=1.C1C2CCCCC(=O)C=2C=CC=1>O>[OH:2][C:3]1[C:4]([Cl:16])=[C:5]([Cl:15])[C:6]2[C:12](=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:14]=1

Participants

5

Reactant 3

HCID 70003BenzosuberoneHCID 10176127Pyridinium chlorideHCID 21483922HCID 21483922, compound

Product 1

HCID 21483890HCID 21483890, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
180 °C

Procedure

2-Methoxy-3,4-dichloro-6,7,8,9-tetrahydro-5H- benzocyclohepten-5-one (25.9 g., 0.1 mole) intimately mixed with pyridine hydrochloride (250 g.) is heated at 180° C. for 1 hour. The hot mixture is poured into water whereupon 2-hydroxy-3,4-dichloro-,6,7,8,9-tetrahydro-5H-benzocyclohepten- 5-one separates and is isolated in the usual way.

Workup

  1. customis isolated in the usual way

Sources & evidence

ORD record
ord-2d0dc58f5b2f4cab9c8a68eeefc52b98
Source dataset
uspto-grants-1977_01
Patent number
US04003927

Reaction notes

Loading…