Ethyl bromoacetate → HCID 21483924, compound

Participants

Reaction Steps

2-Hydroxy-3,4-dichloro-6,7,8,9-tetrahydro-5H- benzocyclohepten- 5-one (10 g., 0.04 mole), anhydrous potassium carbonate (7 g., 0.05 mole) and ethyl bromoacetate (8.35 g., 0.05 mole) in DMF (75 ml.) are stirred at 60° C. for 1 hour. Then potassium hydroxide (5 g.) dissolved in water (5 ml.) and methanol (100 ml.) is added. The mixture is refluxed for one hour. The methanol is distilled, the residue is poured into water, and the solution is filtered. Upon acidification with 12 N NCl, (3,4-dichloro-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten- 2-yloxy)acetic acid separates and is collected by filtration.

Provenance & Evidence