Hydrochloric Acid → HCID 178515108, compound

Participants

Reaction Steps

To a solution of (3,4-dichloro-5-oxo-6-cyclopentyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy)acetonitrile (5.7 g., 0.0165 mole) in DMF (25 ml.) is added sodium azide (1.26 g., 0.0194 mole) and ammonium chloride (1.05 g., 0.0194 mole). The mixture is heated at 85°-90° C. for one hour, cooled and poured into ice water. The mixture is acidified with 6 N HCl. The gummy solid that forms is triturated with butyl chloride and then crystallized from butyl chloride-methanol to obtain 5-(3,4-dichloro-5-oxo-6-cyclopentyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxymethyl)tetrazole.

Provenance & Evidence