Methane → HCID 68121461, compound

Participants

Reaction Steps

17.8 g of 6-methyl-8-oxo-ergoline hydrogen maleate and 23.5 g of 3-aminopyridine in 500 cc of methanol are hydrogenated with the addition of 12 g of 10% palladium on active charcoal under normal conditions. After the hydrogen take up is complete (approx. 120 hours), the catalyst is filtered off, the filtrate is concentrated in a vacuum at a water bath temperature of 60°, and the resulting residue is purified and separated by chromatography on a 30-fold quantity of silica gel with methylene chloride and the addition of increasing amounts of methanol.

Provenance & Evidence