6-Ethoxypyridin-3-amine → 6-Methyl-8-(2-ethoxy-5-pyridylamino)ergoline

HRID 1415296Notes

Reaction equation

HRID 1415296 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][N:5]=1)[CH3:2].[CH3:11][N:12]1[C@H:26]2[C@@H:16]([C:17]3[CH:18]=[CH:19][CH:20]=[C:21]4[C:27]=3[C:24]([CH2:25]2)=[CH:23][NH:22]4)[CH2:15][C:14](=O)[CH2:13]1>[Pd]>[CH3:11][N:12]1[C@H:26]2[C@@H:16]([C:17]3[CH:18]=[CH:19][CH:20]=[C:21]4[C:27]=3[C:24]([CH2:25]2)=[CH:23][NH:22]4)[CH2:15][CH:14]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([O:3][CH2:1][CH3:2])=[N:5][CH:6]=2)[CH2:13]1

Participants

4

Reactant 2

HCID 30403016-Ethoxypyridin-3-amineHCID 116228296-Methyl-8-oxo-ergoline

Product 1

HCID 681215286-Methyl-8-(2-ethoxy-5-pyridylamino)ergoline

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The following compounds (isomers Ia and Ib) are obtained in a manner analogous to that described in Example 3, from 2-ethoxy-5-aminopyridine and 6-methyl-8-oxo-ergoline in the presence of palladium:

Workup

  1. customThe following compounds (isomers Ia and Ib) are obtained in a manner analogous to

Sources & evidence

ORD record
ord-104d651b47cd4402ba5370a38b493c60
Source dataset
uspto-grants-1977_01
Patent number
US04004011

Reaction notes

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