6-Methyl-8-oxo-ergoline → 6-Methyl-8-(2-isopropoxy-5-pyridylamino)ergoline

HRID 1415297Notes

Reaction equation

HRID 1415297 reaction equation
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][N:6]=1)([CH3:3])[CH3:2].[CH3:12][N:13]1[C@H:27]2[C@@H:17]([C:18]3[CH:19]=[CH:20][CH:21]=[C:22]4[C:28]=3[C:25]([CH2:26]2)=[CH:24][NH:23]4)[CH2:16][C:15](=O)[CH2:14]1>[Pd]>[CH3:12][N:13]1[C@H:27]2[C@@H:17]([C:18]3[CH:19]=[CH:20][CH:21]=[C:22]4[C:28]=3[C:25]([CH2:26]2)=[CH:24][NH:23]4)[CH2:16][CH:15]([NH:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[N:6][CH:7]=2)[CH2:14]1

Participants

4

Reactant 2

HCID 116228296-Methyl-8-oxo-ergolineHCID 214841416-(1-Methylethoxy)-3-pyridinamine

Product 1

HCID 681222946-Methyl-8-(2-isopropoxy-5-pyridylamino)ergoline

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The following compounds (isomers Ia and Ib) are obtained in a manner analogous to that described in Example 3, from 2-isopropoxy-5-aminopyridine and 6-methyl-8-oxo-ergoline in the presence of palladium:

Workup

  1. customThe following compounds (isomers Ia and Ib) are obtained in a manner analogous to

Sources & evidence

ORD record
ord-91e1df6cb40849fcb8740037b31ca9b7
Source dataset
uspto-grants-1977_01
Patent number
US04004011

Reaction notes

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