5-Amino-2-butoxypyridine → 6-Methyl-8-(2-n-butoxy-5-pyridylamino)ergoline

HRID 1415298Notes

Reaction equation

HRID 1415298 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][N:7]=1)[CH2:2][CH2:3][CH3:4].[CH3:13][N:14]1[C@H:28]2[C@@H:18]([C:19]3[CH:20]=[CH:21][CH:22]=[C:23]4[C:29]=3[C:26]([CH2:27]2)=[CH:25][NH:24]4)[CH2:17][C:16](=O)[CH2:15]1>[Pd]>[CH3:13][N:14]1[C@H:28]2[C@@H:18]([C:19]3[CH:20]=[CH:21][CH:22]=[C:23]4[C:29]=3[C:26]([CH2:27]2)=[CH:25][NH:24]4)[CH2:17][CH:16]([NH:12][C:9]2[CH:10]=[CH:11][C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[N:7][CH:8]=2)[CH2:15]1

Participants

4

Reactant 2

HCID 683145-Amino-2-butoxypyridineHCID 116228296-Methyl-8-oxo-ergoline

Product 1

HCID 681221326-Methyl-8-(2-n-butoxy-5-pyridylamino)ergoline

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The following compounds (isomers Ia and Ib) are obtained in a manner analogous to that described in Example 3, from 2-n-butoxy-5-aminopyridine and 6-methyl-8-oxo-ergoline in the presence of palladium:

Workup

  1. customThe following compounds (isomers Ia and Ib) are obtained in a manner analogous to

Sources & evidence

ORD record
ord-0782a7903aa8490fb382f39e1146ed42
Source dataset
uspto-grants-1977_01
Patent number
US04004011

Reaction notes

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