HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → 5-Methyl-7-phenyl-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | Ethyl (imidazolidin-2-ylidene)acetate | HCID 12377942 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Methyl-7-phenyl-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester | HCID 68119029 | 81% |
Reaction Steps
Upon heating a solution of 5.3 g of benzaldehyde, 6.5 g of acetoacetic acid ethyl ester and 7.8 g of 2-carbethoxymethylideneimidazolidine in 50 ml of ethanol for 6 hours, 5-methyl-7-phenyl-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester of melting point 165° (alcohol) is obtained. Yield: 81% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04004015 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-d7f49fda0c644a54a82b7c13df7c0c48 |
| Source note | uspto-grants-1977_01 |