HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(furan-2-ylmethylidene)-3-oxobutanoate → 5-Methyl-7-(2-furyl)-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(furan-2-ylmethylidene)-3-oxobutanoate | HCID 252577 | — |
| Reactant | Ethyl (imidazolidin-2-ylidene)acetate | HCID 12377942 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Methyl-7-(2-furyl)-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester | HCID 68119053 | 65% |
Reaction Steps
Boiling a solution of 6.9 g of 2-furfurylideneacetoacetic acid ethyl ester and 5.2 g of 2-carbethoxymethylideneimidazolidine in 50 ml of ethanol for 8 hours yields 5-methyl-7-(2-furyl)-1,2,3,7-tetrahydroimidazolo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester of melting point 164° (ethanol). Yield: 65% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04004015 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-ac6d0094aae341c28db95c1f0b69f5f0 |
| Source note | uspto-grants-1977_01 |