HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylbenzylideneacetoacetic acid ethyl ester → 5-Methyl-7-(2-methylphenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylbenzylideneacetoacetic acid ethyl ester | HCID 54040073 | — |
| Reactant | Ethyl (pyrrolidin-2-ylidene)acetate | HCID 68118984 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Methyl-7-(2-methylphenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid diethyl ester | HCID 12377943 | 62% |
Reaction Steps
Upon boiling a solution of 7.7 g of 2-methylbenzylideneacetoacetic acid ethyl ester and 5.6 g of carbethoxymethylidenepyrrolidine in 50 ml of ethanol for 8 hours, 5-methyl-7-(2-methylphenyl)-1,2,3,7-tetrahydroindolizine-6,8-dicarboxylic acid diethyl ester of melting point 148° (alcohol) is obtained. Yield: 62% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04004015 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-51f263214c8143059703e20378693a77 |
| Source note | uspto-grants-1977_01 |