HCID 131710065, compound → HCID 21484435, compound

HRID 1415325Notes

Reaction equation

HRID 1415325 reaction equation
[CH:1]1([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][C:16]=2[Cl:17])[C:13]([C:18]([OH:20])=[O:19])=[CH:12][CH2:11]3)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>C(O)C.[Ni]>[CH:1]1([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][C:16]=2[Cl:17])[CH:13]([C:18]([OH:20])=[O:19])[CH2:12][CH2:11]3)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

5

Reactant 2

HCID 131710065HCID 131710065, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21484435HCID 21484435, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of 1 g of 5-cycloheptyl-6-chloro-ind-1-ene-1-carboxylic acid in 40 ml of absolute ethanol is hydrogenated with 100 mg of Raney nickel at room temperature and normal pressure until 1 equivalent of hydrogen has been taken up. The catalyst is then filtered off, the filtrate is evaporated to dryness in vacuo and the residue is crystallised from ether/petroleum ether. 5-Cycloheptyl-6-chloro-1-indanecarboxylic acid, thus obtained, melts at 138°-140° C.

Workup

  1. filtrationThe catalyst is then filtered off
  2. customthe filtrate is evaporated to dryness in vacuo
  3. customthe residue is crystallised from ether/petroleum ether

Sources & evidence

ORD record
ord-be0495d0717d41d98ab8317818ad7a41
Source dataset
uspto-grants-1977_01
Patent number
US04004026

Reaction notes

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