Ammonia → HCID 54463297, compound

HRID 1415330Notes

Reaction equation

HRID 1415330 reaction equation
[NH3:1].[CH:2]1([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][C:17]=2[Cl:18])[CH:14]([C:19](Cl)=[O:20])[CH2:13][CH2:12]3)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>C1C=CC=CC=1>[CH:2]1([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][C:17]=2[Cl:18])[CH:14]([C:19]([NH2:1])=[O:20])[CH2:13][CH2:12]3)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54107232HCID 54107232, compound

Product 1

HCID 54463297HCID 54463297, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A vigorous stream of ammonia gas is passed into a solution of 9 g of 5-cycloheptyl-6-chloro-1-indanecarboxylic acid chloride in 150 ml of absolute benzene at 20° C, for 30 minutes, whilst cooling and stirring. The crude amide which precipitates is filtered off, thoroughly washed with water and dried. Two crystallisations from ethanol yield pure 5-cycloheptyl-6-chloro-1-indanecarboxylic acid amide; melting point 170°-171° C.

Workup

  1. temperaturewhilst cooling
  2. customThe crude amide which precipitates
  3. filtrationis filtered off
  4. washthoroughly washed with water
  5. customdried
  6. customTwo crystallisations from ethanol

Sources & evidence

ORD record
ord-a17c48d98e4a4704b6e43ea43c70ffe4
Source dataset
uspto-grants-1977_01
Patent number
US04004026

Reaction notes

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