HCID 178468108, compound → HCID 178468107, compound

HRID 1415337Notes

Reaction equation

HRID 1415337 reaction equation
[NH2:1][C@H:2]([C:5]([NH:7][C@H:8]([C:17]([NH:19][C@@H:20]([C:22]([NH:24][C@H:25]([C:32]([NH:34][C@H:35]([C:43]([N:45]1[CH2:54][CH2:53][CH2:52][C@H:46]1[C:47]([NH:49][CH2:50][CH3:51])=[O:48])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:42])[NH2:41])=[O:33])[CH2:26][S:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:23])[CH3:21])=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)=[O:6])[CH2:3][OH:4].[CH3:55][C:56]([CH2:58][C:59]([OH:61])=[O:60])=[O:57].[NH2:62][C@H:63]([C:69]([NH:71][C@H:72]([C:79]([NH:81][C@H:82]([C:93](NN)=[O:94])[CH2:83][C:84]1[C:92]2[C:87](=[CH:88][CH:89]=[CH:90][CH:91]=2)[NH:86][CH:85]=1)=[O:80])[CH2:73][C:74]1[N:78]=[CH:77][NH:76][CH:75]=1)=[O:70])[CH2:64][CH2:65][C:66](=[O:68])[OH:67]>>[NH2:62][C@H:63]([C:69]([NH:71][C@H:72]([C:79]([NH:81][C@H:82]([C:93]([NH:1][C@H:2]([C:5]([NH:7][C@H:8]([C:17]([NH:19][C@@H:20]([C:22]([NH:24][C@H:25]([C:32]([NH:34][C@H:35]([C:43]([N:45]1[CH2:54][CH2:53][CH2:52][C@H:46]1[C:47]([NH:49][CH2:50][CH3:51])=[O:48])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:41])[NH2:42])=[O:33])[CH2:26][S:27][C:28]([CH3:30])([CH3:31])[CH3:29])=[O:23])[CH3:21])=[O:18])[CH2:9][C:10]1[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=1)=[O:6])[CH2:3][OH:4])=[O:94])[CH2:83][C:84]1[C:92]2[C:87](=[CH:88][CH:89]=[CH:90][CH:91]=2)[NH:86][CH:85]=1)=[O:80])[CH2:73][C:74]1[N:78]=[CH:77][NH:76][CH:75]=1)=[O:70])[CH2:64][CH2:65][C:66](=[O:67])[OH:68].[CH3:55][C:56]([CH2:58][C:59]([OH:61])=[O:60])=[O:57]

Participants

3

Reactant 2

HCID 178468108HCID 178468108, compoundHCID 178514448HCID 178514448, compound

Product 1

HCID 178468107HCID 178468107, compound

Procedure

In analogy to Example 7(e) 448.5 mg (0.5 mol) of H-Ser-Tyr-D-Ala-Cys(But)-Arg-Pro-NH-C2H5 -diacetate were reacted with Glu-His-Trp-NH-NH2, worked up and purified over Dowex 1 × 2 (acetate form) and carboxymethyl cellulose. Since the substance was not completely pure, it was purified in analogy to Example 1(a) on Sephadex LH 20.

Workup

  1. custompurified over Dowex 1 × 2 (acetate form) and carboxymethyl cellulose
  2. customit was purified in analogy to Example 1(a) on Sephadex LH 20

Sources & evidence

ORD record
ord-310ef94f620243f3b88d0ec026b96c0b
Source dataset
uspto-grants-1977_01
Patent number
US04003884

Reaction notes

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