Hydrochloric Acid → HCID 178465163, compound

Participants

Reaction Steps

In analogy to Example 8(b) 3.6 g (6.8 mmols) of H-Cys(But)-Arg-Pro-NH-C2H5 . 2 HCl were reacted with 3 g of Z-D-Leu-OTcp and worked up. The oily residue (6.1 g of contaminated Z-D-Leu-Cys(But)-Arg-Pro-NH--C2H5) was hydrogenated catalytically in analogy to Example 8(b). Yield: 2.5 g (57%). The compound was strongly contaminated and purified over Sephadex LH 20 in analogy to Example 1(a). Yield: 1.734 g (40%) of H-D-Leu-Cys(But)-Arg-Pro-NH-C2H5 -diacetate. The 1.734 g (2.7 mmols) of H-D-Leu-Cys(But)-Arg-Pro-NH-C2H5 -acetate were reacted in analogy to Example 8(b) with 1.33 g of Z-Ser-Tyr(Bzl)-OH, 0.71 ml of N-ethyl morpholine, 3.65 mg of HOBt and 595 mg of DCC in 5 ml of dimethylformamide and worked up. The substance obtained (2.45 g of Z-Ser-Tyr(Bzl)-D-Leu-Cys(But)-Arg-Pro-NH-C2H5) was hydrogenated catalytically in analogy to Example 8(b) and purified over Sephadex LH 20.

Provenance & Evidence