HCID 178468106, compound → HCID 178468105, compound

HRID 1415339Notes

Reaction equation

HRID 1415339 reaction equation
[NH2:1][C@H:2]([C:5]([NH:7][C@H:8]([C:17]([NH:19][C@@H:20]([C:25]([NH:27][C@H:28]([C:35]([NH:37][C@H:38]([C:46]([N:48]1[CH2:57][CH2:56][CH2:55][C@H:49]1[C:50]([NH:52][CH2:53][CH3:54])=[O:51])=[O:47])[CH2:39][CH2:40][CH2:41][NH:42][C:43](=[NH:45])[NH2:44])=[O:36])[CH2:29][S:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:26])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)=[O:6])[CH2:3][OH:4].[CH3:58][C:59]([CH2:61][C:62]([OH:64])=[O:63])=[O:60].[NH2:65][C@H:66]([C:72]([NH:74][C@H:75]([C:82]([NH:84][C@H:85]([C:96](NN)=[O:97])[CH2:86][C:87]1[C:95]2[C:90](=[CH:91][CH:92]=[CH:93][CH:94]=2)[NH:89][CH:88]=1)=[O:83])[CH2:76][C:77]1[N:81]=[CH:80][NH:79][CH:78]=1)=[O:73])[CH2:67][CH2:68][C:69](=[O:71])[OH:70]>>[NH2:65][C@H:66]([C:72]([NH:74][C@H:75]([C:82]([NH:84][C@H:85]([C:96]([NH:1][C@H:2]([C:5]([NH:7][C@H:8]([C:17]([NH:19][C@@H:20]([C:25]([NH:27][C@H:28]([C:35]([NH:37][C@H:38]([C:46]([N:48]1[CH2:57][CH2:56][CH2:55][C@H:49]1[C:50]([NH:52][CH2:53][CH3:54])=[O:51])=[O:47])[CH2:39][CH2:40][CH2:41][NH:42][C:43](=[NH:44])[NH2:45])=[O:36])[CH2:29][S:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:26])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:18])[CH2:9][C:10]1[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=1)=[O:6])[CH2:3][OH:4])=[O:97])[CH2:86][C:87]1[C:95]2[C:90](=[CH:91][CH:92]=[CH:93][CH:94]=2)[NH:89][CH:88]=1)=[O:83])[CH2:76][C:77]1[N:81]=[CH:80][NH:79][CH:78]=1)=[O:73])[CH2:67][CH2:68][C:69](=[O:70])[OH:71].[CH3:58][C:59]([CH2:61][C:62]([OH:64])=[O:63])=[O:60]

Participants

3

Reactant 2

HCID 178468106HCID 178468106, compoundHCID 178514448HCID 178514448, compound

Product 1

HCID 178468105HCID 178468105, compound

Procedure

In analogy to Example 7(e) 469.5 mg (0.5 mol) of H-Ser-Tyr-D-Leu-Cys(But)-Arg-Pro-NH-C2H5 -diacetate were reacted with Glu-His-Trp-NH-NH2, worked up and purified over Dowex 1 × 2 (acetate form) and carboxymethyl cellulose. Since the substance was not yet completely pure it was purified in analogy to Example 1(a) on Sephadex LH 20.

Workup

  1. custompurified over Dowex 1 × 2 (acetate form) and carboxymethyl cellulose
  2. customwas purified in analogy to Example 1(a) on Sephadex LH 20

Sources & evidence

ORD record
ord-739f13e138c64860a8028d8498f676aa
Source dataset
uspto-grants-1977_01
Patent number
US04003884

Reaction notes

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