1-Chloro-4-nitrobenzene → HCID 15739784, compound

Participants

Reaction Steps

75 g of 4-chloronitrobenzene in 300 ml of ethanol is heated to 70°. At this temperature there is then added dropwise 27 g of anhydrous potassium hydroxide and 65.9 g of 2-phenylethyl mercaptan in 250 ml of ethanol; the reaction mixture is refluxed for one hour and is then poured, with stirring into 1.5 liters of ice-water. The precipitated oil is extracted with methylene chloride, and the methylene chloride phases are dried over sodium sulphate. After purification through silica gel with methylene chloride as the eluant, there is obtained 4-(2'-phenyl-ethylthio)-nitrobenzene having a melting point of 35° - 37°.

Provenance & Evidence