Hydrazine → HCID 178514368, compound

HRID 1415395Notes

Reaction equation

HRID 1415395 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[C:9]([Cl:12])[CH:10]=[CH:11][C:6]=2[CH2:5][O:4][N:3]=1.[NH2:13][NH2:14]>C(O)C>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]2[CH2:5][O:4][N:3]=[C:2]([NH:13][NH2:14])[C:7]=2[CH:8]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 21482149HCID 21482149, compound

Product 1

HCID 178514368HCID 178514368, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

An amount of 3.6 g. of 4,6-dichloro-1H-2,3-benzoxazine and 1.8 ml. of anhydrous hydrazine are dissolved in 18 ml. of absolute ethanol and refluxed for 30 minutes. The mixture is allowed to cool, then is distilled in vacuo. The residue is taken up with methylene chloride and filtered from precipitated hydrazine hydrochloride. The filtered solution is distilled to dryness and the residue crystallized from ethanol. An amount of 2.10 g. of 6-chloro-4-hydrazino-1H-2,3-benzoxazine is obtained.

Workup

  1. temperatureto cool
  2. distillationis distilled in vacuo
  3. filtrationfiltered
  4. customfrom precipitated hydrazine hydrochloride
  5. distillationThe filtered solution is distilled to dryness
  6. customthe residue crystallized from ethanol

Sources & evidence

ORD record
ord-56603f0363964fd1841ce7b333d6a3b4
Source dataset
uspto-grants-1977_01
Patent number
US04005082

Reaction notes

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