HCID 57289127, compound → HCID 21482374, compound

Participants

Reaction Steps

15.2 G of 1-cyclopropyl-3-(p-chlorophenyl)-4-methyl-4-nitropentanone in 250 ml of methanol are hydrogenated for 7 hours 30 minutes under 100 atmospheres at 120° C in the presence of 10 g of Raney Nickel. Filtration, evaporation of the methanolic filtrate under reduced pressure and recrystallisation from isopropanol give 9 g of 2-cyclopropyl-4-phenyl-5,5-dimethylpyrrolidine hydrochloride as white crystals. Melting point = 271°-273° C.

Provenance & Evidence