Ammonia → HCID 21482389, compound

Participants

Reaction Steps

15.3 G of 1-cyclopropyl-3-(p-chlorophenyl)-4-methyl-4-nitropentanone in 200 ml of ethanol saturated with ammonia are hydrogenated for 7 hours 30 minutes under 100 atmospheres at 120° C in the presence of 8 g of Raney Nickel. After filtration and concentration of the filtrate in vacuo, the residue is diluted with ethanol-ether (50:50) and the base is neutralised with hydrogen chloride in ether. The precipitate so obtained is filtered off, washed with ether and recrystallized from isopropanol to give 9.5 g of 2-cyclopropyl-4-(p-chlorophenyl)-5,5-dimethyl-pyrrolidine hydrochloride as white crystals. Melting point = 235°-240° C.

Provenance & Evidence