Acetic Anhydride → HCID 12491129, compound

HRID 1415434Notes

Reaction equation

HRID 1415434 reaction equation
O=[C:2]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:14][CH2:15][C:16]([OH:18])=[O:17].C(OC(=O)C)(=O)C>C(O)(=O)C>[C:3]12[CH2:14][CH2:15][C:16](=[O:17])[O:18][C:2]=1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]2

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 27750833-(2-oxocyclododecyl)propanoic acid

Product 1

HCID 12491129HCID 12491129, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

One part of β-(2-oxocyclododecyl)propionic acid, 1 part of acetic anhydride, 10 parts of glacial acetic acid, and 0.5 part of Amberlyst 15 were allowed to react at 50° C for 4 hours and the reaction solution was withdrawn and analyzed by gas chromatography to find that β-(2-oxocyclododecyl)propionic acid was not present and 13-oxabicyclo(10.4.0)hexadec-1(12)-en-14-one was produced in 99% selectivity.

Workup

  1. customto react at 50° C for 4 hours
  2. customthe reaction solution was withdrawn

Sources & evidence

ORD record
ord-87c32d27c2bf4d37bd2eeb7ffe8f8fd2
Source dataset
uspto-grants-1977_01
Patent number
US04005107

Reaction notes

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