3-(2-oxocyclododecyl)propanoic acid → HCID 12491129, compound

Participants

Reaction Steps

Into a column of 1.6 mm diameter was packed Amberlyst 15 and a solution composed of β-(2-oxocyclododecyl)propionic acid, acetic anhydride, and glacial acetic acid in the ratio of 1:1:10 parts by weight was flowed down through the column at a residence time of 5 hours. The effluent was fractionally cut each hour and each fraction was analyzed by gas chromatography. The gas chromatogram of the reaction solution after 5 hours from outset of the flow-down showed that β-(2-oxocyclododecyl)-propionic acid was not present and 13-oxabicyclo(10.4.0)hexadec-1(12)-en-14-one was produced in 99% yield.

Provenance & Evidence