4-Acetylamino-3,5-bis-trifluoromethylnitrobenzene → HCID 21482728, compound

HRID 1415499Notes

Reaction equation

HRID 1415499 reaction equation
[C:1]([NH:4][C:5]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][C:8]([N+:15]([O-])=O)=[CH:7][C:6]=1[C:18]([F:21])([F:20])[F:19])(=[O:3])[CH3:2].[H][H]>[Pd].C(O)C>[C:1]([NH:4][C:5]1[C:6]([C:18]([F:20])([F:21])[F:19])=[CH:7][C:8]([NH2:15])=[CH:9][C:10]=1[C:11]([F:12])([F:13])[F:14])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 214827254-Acetylamino-3,5-bis-trifluoromethylnitrobenzeneHCID 178418361HCID 178418361, compound

Product 1

HCID 21482728HCID 21482728, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 7.9 g. of 4-acetylamino-3,5-bis-trifluoromethylnitrobenzene in 200 ml. of ethanol is hydrogenated under 40 lbs. of hydrogen pressure with 1 g. of 5% palladium on charcoal catalyst. When the calculated amount of hydrogen is consumed, the solution is filtered and concentrated in vacuo to give 4-acetylamino-3,5-bis-trifluoromethylaniline.

Workup

  1. customWhen the calculated amount of hydrogen is consumed
  2. filtrationthe solution is filtered
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-86fb91bf365244c08b96b03febeae2aa
Source dataset
uspto-grants-1977_01
Patent number
US04005199

Reaction notes

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