Nitric Acid → HCID 21482747, compound

HRID 1415501Notes

Reaction equation

HRID 1415501 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([Cl:14])(=[O:13])=[O:12])=[CH:7][C:6]=1[C:15]([F:18])([F:17])[F:16])(=[O:3])[CH3:2].S(=O)(=O)(O)O.[N+:24]([O-])([OH:26])=[O:25]>>[C:1]([NH:4][C:5]1[C:6]([C:15]([F:18])([F:17])[F:16])=[CH:7][C:8]([S:11]([Cl:14])(=[O:12])=[O:13])=[CH:9][C:10]=1[N+:24]([O-:26])=[O:25])(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 21482740HCID 21482740, compound

Product 1

HCID 21482747HCID 21482747, compound

Procedure

3.0 G. of 4-acetylamino-3-trifluoromethylbenzenesulfonylchloride is dissolved in 15 ml. of concentrated sulfuric acid. 0.9 Moles of nitric acid is added dropwise over a period of 15 minutes, while the temperature is kept below 35° C. When the addition is complete the reaction mixture is stirred at room temperature for 2 hours. The reaction mixture is poured onto 150 ml. of ice water and the precipitate is filtered, washed with water and dried affording 4-acetylamino-3-nitro-5-trifluoromethylbenzenesulfonylchloride, used directly in the next step.

Workup

  1. customis kept below 35° C
  2. additionWhen the addition
  3. additionThe reaction mixture is poured onto 150 ml
  4. filtrationof ice water and the precipitate is filtered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-840ccdb06258449cb628a74c8d5b5e17
Source dataset
uspto-grants-1977_01
Patent number
US04005199

Reaction notes

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