Methyl iodide → HCID 21447157, compound

HRID 1415513Notes

Reaction equation

[F:1][C:2]([F:30])([F:29])[CH2:3][O:4][C:5]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][C:25]([F:28])([F:27])[F:26])=[CH:19][C:6]=1[C:7]([NH:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][N:12]1[CH2:17][CH3:18])=[O:8].[CH3:31][I:32]>>[I-:32].[F:30][C:2]([F:1])([F:29])[CH2:3][O:4][C:5]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][C:25]([F:28])([F:27])[F:26])=[CH:19][C:6]=1[C:7]([NH:9][CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][N+:12]1([CH2:17][CH3:18])[CH3:31])=[O:8]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 21447156HCID 21447156, compound

Product 1

HCID 21447157HCID 21447157, compound

Procedure

Using the method of Example 37, 2,5-bis(2,2,2-trifluoroethoxy)-N-[(1-ethyl-2-piperidyl)methyl]benzamide is reacted with methyl iodide to provide 2-[2,5-bis(2,2,2-trifluoroethoxy)benzamidomethyl]-1-ethyl-1-methylpiperidinium iodide as a white solid, m.p. 162° -165° C.

Sources & evidence

ORD record: ord-73182694448e4b37b06d50397ffc4127
Source dataset: uspto-grants-1977_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04005209

Reaction notes

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