HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Nitro-5-[(pyrimidin-2-yl)sulfanyl]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Chloro-2-nitroaniline | HCID 74218 | — |
| Reactant | HCID 178418793 | HCID 178418793 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Nitro-5-[(pyrimidin-2-yl)sulfanyl]aniline | HCID 21482775 | — |
Reaction Steps
A mixture of 3.5 g. of 2-amino-4-chloro-1-nitrobenzene, 5.5 g. of potassium carbonate, and 4.5 g. of 2-mercaptopyrimidine in 25 ml. dimethylformamide is heated overnight under nitrogen at 105°-110° C. The mixture is cooled, diluted with water and the product filtered off. Recrystallization from methanol yields 2-amino-1-nitro-4-(pyrimidin-2-ylthio)benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04005202 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-29bfbba4b845423d827ead892c8ed79e |
| Source note | uspto-grants-1977_01 |