HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-[(1-Methyl-1H-imidazol-2-yl)sulfanyl]-2-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Chloro-2-nitroaniline | HCID 74218 | — |
| Reactant | HCID 178480602 | HCID 178480602 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-[(1-Methyl-1H-imidazol-2-yl)sulfanyl]-2-nitroaniline | HCID 21482789 | — |
Reaction Steps
A mixture of 2.5 G. of 2-amino-4-chloro-1-nitrobenzene, 3.4 g. of 1-methyl-2-mercapto-imidazole and 4.2 g. potassium carbonate in 20 ml. dimethylformamide is heated overnight at 110°-120° C., then cooled, and poured into water. The product is filtered off and recrystallized from aqueous methanol to give 2-amino-4-(1-methylimidazol-2-ylthio)-1-nitrobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04005202 |
| Source dataset | uspto-grants-1977_01 |
| ORD ID | ord-d4ddb38805a4419b8a7d277fc73d09d9 |
| Source note | uspto-grants-1977_01 |