3-amino-N-ethylpiperidine → HCID 21482860, compound

Participants

Reaction Steps

A solution of 4.0 g. of 9-acetoxyxanthene and 2.36 g. of 3-amino-1-ethylpiperidine in 175 ml. of dry toluene was refluxed for 24 hours. The cooled solution was then concentrated in vacuo. The residue was chromatographed on activated magnesium silicate, eluting with ether and acetone. Concentration of the acetone fraction in vacuo and then chromatographing on silica gel with acetone, then concentrating the eluate in vacuo gave N-(N-ethyl-3-piperidinyl)-9-xanthenylamine, m.p. 47.5°-48.5° C.

Provenance & Evidence