Potassium Hydroxide → N-(4-piperidinyl)-9-xanthenylamine

HRID 1415551Notes

Reaction equation

HRID 1415551 reaction equation
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][CH:13]2[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:20][C:19]3[C:14]2=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:8][CH2:7]1)=O)C.[OH-].[K+]>C(O)C>[NH:6]1[CH2:7][CH2:8][CH:9]([NH:12][CH:13]2[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:20][C:19]3[C:14]2=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 21482840N-(N-ethoxycarbonyl-4-piperidinyl)-9-xanthenylamine

Product 1

HCID 21482835N-(4-piperidinyl)-9-xanthenylamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5 g. of N-(N-ethoxycarbonyl-4- piperidinyl)-9-xanthenylamine, prepared as in Example 14, and 25 g. of potassium hydroxide in 125 ml. of aqueous ethanol is heated at reflux for three hours and then cooled and added with stirring to 1 liter of ice water. The mixture is extracted with ether and the extracts dried and concentrated in vacuo to give N-(4-piperidinyl)-9-xanthenylamine.

Workup

  1. additionA mixture of 5 g
  2. temperatureat reflux for three hours
  3. temperaturecooled
  4. additionadded
  5. extractionThe mixture is extracted with ether
  6. customthe extracts dried
  7. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-292bcbc55f36452aa47c0a85587a0155
Source dataset
uspto-grants-1977_01
Patent number
US04005208

Reaction notes

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