HCID 21482850, compound → 2-(1-Cyclohexylpyrrolidin-3-yl)-1H-isoindole-1,3(2H)-dione

Participants

Reaction Steps

A rapidly stirred suspension of 160 g. of N-cyclohexyl-3-chloropyrrolidine, 148 g. of potassium phthalimide and 700 ml. of dimethyl sulfoxide is heated at 110°-113° C. for 16 hours and filtered while hot. Water is added and the precipitate is filtered off, washed with water, air-dried and recrystallized from iso-octane-benzene to give 1-cyclohexyl-3-phthalimidopyrrolidine.

Provenance & Evidence