2,6-Difluorobenzoyl isocyanate → Diphenyl Ether

Participants

Reaction Conditions

Reaction Steps

A solution of 3.7 g (0.02 mole) of 2,6-difluorobenzoylisocyanate in 20 ml of toluene was added dropwise at 50° C to a solution of 5.6 g (0.02 mole) of 4-(2'-chloro-4'-nitrophenoxy)-2-methylaniline in 100 ml of toluene. The batch was stirred for 1 hour at 60° C. The substance which separated out was filtered off after cooling the reaction mixture to 20° C and was washed with toluene and petroleum ether. After drying, 7 g (75% of theory) of 2-chloro-4-nitro-3'-methyl-4'-[N-(N'-2,6-difluorobenzoyl))-ureido]-diphenyl ether of melting point 190° C were obtained.

Provenance & Evidence