Ammonium Chloride → HCID 21483136, compound

Participants

Reaction Conditions

Reaction Steps

20 parts of iron-powder are added to 190 parts of ammonium chloride solution 0.78N at reflux temperature. Then there is added dropwise a solution of 20 parts of 2,4-dichloro-α-(4-nitrophenyl)benzeneacetonitrile in 180 parts of methylbenzene. Upon completion, stirring is continued overnight at reflux. The reaction mixture is cooled at 60° C and filtered over hyflo. The filter-cake is washed with tetrahydrofuran. The filtrate is dried, filtered and evaporated. The residue is converted into the hydrochloride salt in 2,2'-oxybispropane, methanol and 2-propanol. The salt is filtered off and dried, yielding α-(4-aminophenyl)-2,4-dichlorobenzeneacetonitrile hydrochloride; mp. 207.2° C.

Provenance & Evidence