反应详情

A solution of 2-[[7-chloro-5-(2-pyridyl)-3H-1,4-benzodiazepin-2-yl]amino]propionaldehyde dimethyl acetal in monoglyme is treated with titanium tetrachloride first at room temperature, then under reflux. The reaction mixure is cooled, neutralized, and extracted with chloroform. The chloroform layer is concentrated in vacuo and the resulting residue crystallized to give 8-chloro-2-methyl-6-(2-pyridyl)-4H-imidazo[1,2-a][1,4]benzodiazepine.

1. temperatureunder reflux
2. temperatureThe reaction mixure is cooled
3. extractionextracted with chloroform
4. concentrationThe chloroform layer is concentrated in vacuo
5. customthe resulting residue crystallized