反应详情

4-n-Butyl-2-nitroaniline (25-g; 0.13 mole) and formic acid (25 g; 0.54 mole) were mixed together at laboratory temperature and the mixture was then refluxed for forty minutes. After cooling to laboratory temperature the clear solution was poured into water (500 ml) and the orange solid which separated was filtered off, washed with water, dried and crystallised from light petroleum (b.p. 60°-80° C.) to give 5-n-butyl-2-formamido-1-nitrobenzene (20 g), m.p. 72°-73° C.

1. temperaturethe mixture was then refluxed for forty minutes
2. temperatureAfter cooling to laboratory temperature the clear solution
3. customthe orange solid which separated
4. filtrationwas filtered off
5. washwashed with water
6. customdried
7. customcrystallised from light petroleum (b.p. 60°-80° C.)