HCID 21441048, compound → HCID 21483003, compound

HRID 1415629Notes

Reaction equation

HRID 1415629 reaction equation
[CH3:1][O:2][C:3]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([O:18][CH:19]([CH3:21])[CH3:20])=[O:17])=[CH:11][C:10]=1[NH2:22])=[S:7])=[O:4].[CH2:23]([O:25][C:26]([NH:28][C:29]([NH:31][C:32]1[CH:37]=[CH:36][C:35]([NH:38][C:39]([O:41][CH:42]([CH3:44])[CH3:43])=[O:40])=[CH:34][C:33]=1[NH2:45])=[S:30])=[O:27])[CH3:24].COC(NC(NC1C=CC(CCCC)=CC=1N)=S)=O>>[CH3:1][O:2][C:3]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([O:18][CH:19]([CH3:20])[CH3:21])=[O:17])=[CH:11][C:10]=1[NH:22][C:23](=[O:25])[CH3:24])=[S:7])=[O:4].[CH2:23]([O:25][C:26]([NH:28][C:29]([NH:31][C:32]1[CH:37]=[CH:36][C:35]([NH:38][C:39]([O:41][CH:42]([CH3:44])[CH3:43])=[O:40])=[CH:34][C:33]=1[NH:45][C:19](=[O:18])[CH3:20])=[S:30])=[O:27])[CH3:24]

Participants

5

Reactant 3

HCID 21441048HCID 21441048, compoundHCID 21482974HCID 21482974, compoundHCID 21483080HCID 21483080, compound

Product 2

HCID 21483003HCID 21483003, compoundHCID 21483023HCID 21483023, compound

Procedure

By proceeding in a similar manner but substituting an equimolecular quantity of 1-methoxycarbonyl-3-(2-amino-4-isopropoxycarbonylaminophenyl)thiourea and 1-ethoxycarbonyl-3-(2-amino-4-isopropoxycarbonylaminophenyl)thiourea for 1-methoxycarbonyl-3-(2-amino-4-n-butylphenyl)thiourea, there were obtained 1-methoxycarbonyl-3-(2-acetamido-4-isopropoxycarbonylaminophenyl)thiourea, m.p. 187°-188° C. (with decomposition) and 1-ethoxycarbonyl-3-(2-acetamido-4-isopropoxycarbonylaminophenyl)thiourea, m.p. 201°-202° C. (with decomposition), respectively.

Sources & evidence

ORD record
ord-9b647aa3e3a64367a70f02912af62d00
Source dataset
uspto-grants-1977_01
Patent number
US04005217

Reaction notes

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