Formic Acid → HCID 54232761, compound

HRID 1415630Notes

Reaction equation

HRID 1415630 reaction equation
[CH3:1][O:2][C:3]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH3:18])=[CH:11][C:10]=1[NH2:19])=[S:7])=[O:4].[CH:20](O)=[O:21]>O>[CH3:1][O:2][C:3]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH3:18])=[CH:11][C:10]=1[NH:19][CH:20]=[O:21])=[S:7])=[O:4]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 21441048HCID 21441048, compound

Product 1

HCID 54232761HCID 54232761, compoundYield 73.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Methoxycarbonyl-3-(2-amino-4-n-butylphenyl)thiourea (15.0 g; 0.053 mole) and formic acid (18.4 g; 0.4 mole) were mixed together at laboratory temperature and the mixture was refluxed for forty minutes. The hot clear solution was then poured into water, and the solid which separated was filtered off, washed with water, dried and crystallised from 2-ethoxyethanol to give 1-methoxycarbonyl-3-(4-n-butyl-2-formamidophenyl)thiourea (12.0 g), m.p. 182°-183° C. (with decomposition).

Workup

  1. temperaturethe mixture was refluxed for forty minutes
  2. customthe solid which separated
  3. filtrationwas filtered off
  4. washwashed with water
  5. customdried
  6. customcrystallised from 2-ethoxyethanol

Sources & evidence

ORD record
ord-a6028a9c55624da6b2dd137c106bd704
Source dataset
uspto-grants-1977_01
Patent number
US04005217

Reaction notes

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