反应详情

A suspension of N-(4-n-butyl-2-nitrophenyl)-2-bromoacetamide (41 g) in ethanol (200 ml) was treated with a solution of dimethylamine in ethanol (90 ml of 20% w/w). The mixture was refluxed for one hour and the ethanol was evaporated off. Water (100 ml) was added and the mixture extracted with diethyl ether (3 × 200 ml). The extract was dried over magnesium sulphate, filtered and evaporated to give N-(4-n-butyl-2-nitrophenyl)-2-dimethylaminoacetamide as a yellow oil which was used without further purification in the next stage.

1. temperatureThe mixture was refluxed for one hour
2. customthe ethanol was evaporated off
3. additionWater (100 ml) was added
4. extractionthe mixture extracted with diethyl ether (3 × 200 ml)
5. dry with materialThe extract was dried over magnesium sulphate
6. filtrationfiltered
7. customevaporated