N-(4-methoxycarbonylamino-2-nitrophenyl)-2-dimethylaminoacetamide → N-(2-amino-4-methoxycarbonylaminophenyl)-2-dimethylaminoacetamide

Participants

Reaction Steps

N-(4-methoxycarbonylamino-2-nitrophenyl)-2-dimethylaminoacetamide (25.3 g), platinum oxide (0.4 g) and methanol (250 ml) were shaken together in an atmosphere of hydrogen at atmospheric pressure and laboratory temperature until the uptake of hydrogen was complete. Six litres of hydrogen were absorbed. The mixture was filtered and the ethanol evaporated. The residual solid was recrystallised from isopropanol to give N-(2-amino-4-methoxycarbonylaminophenyl)-2-dimethylaminoacetamide (15.7 g), m.p. 140°-142° C.

Provenance & Evidence