Dimethylamine → HCID 21483012, compound

Participants

Reaction Steps

A suspension of dimethylamine in ethanol (20% w/w; 18 ml) was added to a suspension of 1-methoxycarbonyl-3-[2-(3-chloropropionamido)phenyl]thiourea (8.2 g) in ethanol (50 ml). The mixture was heated under reflux, with stirring, for 30 minutes, the ethanol removed by distillation and water (10 ml) added to the residual gum which slowly solidified. The solid was filtered off and dissolved in the minimum of ethanol. Diethyl ether (300 ml) was added, followed by an excess of a saturated solution of hydrogen chloride in diethyl ether. The precipitated solid was filtered off and recrystallised from ethanol to give 1-methoxycarbonyl-3-[2-(3-dimethylaminopropionamido)phenyl]thiourea hydrochloride (3.3 g), m.p. 182°-183° C. (with decomposition).

Provenance & Evidence