HCID 474636, compound → HCID 178435267, compound

Participants

Reaction Steps

A solution of 5,11-dihydro-11-ethyl-2-methoxy-5-methyl-dipyrido[3,2-b:2',3'-e]azepine-6-one (0.181 g) in acetic acid (1 mL) and 48% HBr in acetic acid (1 mL) was heated at 110° C. for 10 minutes. The mixture was cooled, neutralized with saturated sodium bicarbonate, and extracted with chloroform. The organic phase was dried, filtered and evaporated to give 5,11-dihydro-11-ethyl-2-hydroxy-5-methyl-dipyrido[3,2-b:2',3'-e]azepine-6-one (0.176 g) which was used directly in the next reaction.

Provenance & Evidence